|
KMID : 0361019980410121562
|
|
Korean Journal of Otolaryngology - Head and Neck Surgery
1998 Volume.41 No. 12 p.1562 ~ p.1566
|
|
|
Treatment Outcomes of Olfactory Neuroblastoma: A Report of 5 Cases.
|
|
Yun Ju-Hyun
Kim Sung-Shik
Choi Young-Jun
Kim Kyung-Su
Kim Young-Ho
|
|
|
Abstract
|
|
|
Background and Objectibes: Several strategies have been reported for the treatment of olfactory neuroblastoma such as radiation therapy, chemotherapy, craniofacial resection, or their combination. However, a consensus regarding the optimal management has not been obtained. In this study, we examined the outcomes of different treatment modalities in five patients with olfactory neuroblastoma.
Material and Methods: Five patients diagnosed as olfactory neuroblastoma during the past 10 years were retrospectively analyzed.
Results: Five patients were categorized by the modified Kadish’s staging system. Three patients underwent surgery. Radiotherapy was given concurrently with chemotherapy for two patients. Distant metastases were observed in two cases, one in the heart and the other in the cervical lymph node. After a median follow-up of 34 (12-87) months, two patients who underwent craniofacial resection only and another two patients who received combined radiotherapy and chemotherapy are still alive. One patient who underwent Denker’s operation with postoperative radiotherapy had died of heart failure as a result of cardiac metastasis.
Conclusion: We suggest a complete surgical resection as a primary treatment modality, however, a multi-drug chemotherapy with radiotherapy could be the choice of treatment in cases of children or one with distant metastasis.
|
|
|
KEYWORD
|
|
|
Olfactory neuroblastoma, Treatment outcome
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
  
|